| 1 | |  CF America | 17 | 10 | 5 | 2 | 21 | 10 | 11 | 35 | G03:05 | 20/10/21 | R 14  CF America 2 Club Santos Laguna 1 G03:00 | 24/10/21 | R 15 CF America 1 Tigres UANL 0 M02:05 | 01/11/21 | R 16 Cruz Azul 2 CF America 1 B04:00 | 07/11/21 | R 17 CF America 0 CF Monterrey 0 B04:00 | 25/11/21 | R quarterfinal Pumas Unam 0 CF America 0 M04:00 | 28/11/21 | R quarterfinal CF America 1 Pumas Unam 3 |
| 2 | |  Atlas FC | 17 | 8 | 5 | 4 | 21 | 10 | 11 | 29 | B06:05 | 25/11/21 | R quarterfinal CF Monterrey 0 Atlas FC 0 B06:05 | 28/11/21 | R quarterfinal Atlas FC 1 CF Monterrey 1 G06:00 | 03/12/21 | R semifinal Pumas Unam 0 Atlas FC 1 M04:00 | 06/12/21 | R semifinal Atlas FC 0 Pumas Unam 1 M06:00 | 10/12/21 | R final Club Leon 3 Atlas FC 2 G05:15 | 13/12/21 | R final Atlas FC (4) 1 Club Leon (3) 0 |
| 3 | |  Club Leon | 17 | 8 | 5 | 4 | 20 | 14 | 6 | 29 | M04:00 | 26/11/21 | R quarterfinal Puebla FC 2 Club Leon 1 G05:05 | 29/11/21 | R quarterfinal Club Leon 2 Puebla FC 0 M06:00 | 02/12/21 | R semifinal Tigres UANL 2 Club Leon 1 G06:00 | 05/12/21 | R semifinal Club Leon 2 Tigres UANL 1 G06:00 | 10/12/21 | R final Club Leon 3 Atlas FC 2 M05:15 | 13/12/21 | R final Atlas FC (4) 1 Club Leon (3) 0 |
| 4 | |  Tigres UANL | 17 | 7 | 7 | 3 | 26 | 14 | 12 | 28 | G05:10 | 31/10/21 | R 16 Tigres UANL 2 Guadalajara Chivas 1 G06:00 | 07/11/21 | R 17 Tigres UANL 3 FC Juarez 0 M06:05 | 26/11/21 | R quarterfinal Club Santos Laguna 2 Tigres UANL 1 G03:00 | 29/11/21 | R quarterfinal Tigres UANL 1 Club Santos Laguna 0 G06:00 | 02/12/21 | R semifinal Tigres UANL 2 Club Leon 1 M06:00 | 05/12/21 | R semifinal Club Leon 2 Tigres UANL 1 |
| 5 | |  Club Santos Laguna | 17 | 5 | 9 | 3 | 23 | 16 | 7 | 24 | G01:00 | 31/10/21 | R 16 Queretaro FC 2 Club Santos Laguna 3 G04:00 | 05/11/21 | R 11 Pumas Unam 0 Club Santos Laguna 3 B04:06 | 08/11/21 | R 17 Club Santos Laguna 0 Atletico San Luis 0 G04:00 | 21/11/21 | R 1 Club Santos Laguna 2 Atletico San Luis 0 G06:05 | 26/11/21 | R quarterfinal Club Santos Laguna 2 Tigres UANL 1 M03:00 | 29/11/21 | R quarterfinal Tigres UANL 1 Club Santos Laguna 0 |
| 6 | |  Deportivo Toluca FC | 17 | 6 | 6 | 5 | 22 | 22 | 0 | 24 | M01:00 | 18/10/21 | R 13 Guadalajara Chivas 2 Deportivo Toluca FC 0 B03:00 | 21/10/21 | R 14 Deportivo Toluca FC 1 Necaxa 1 B03:06 | 25/10/21 | R 15 Club Santos Laguna 2 Deportivo Toluca FC 2 B21:00 | 31/10/21 | R 16 Deportivo Toluca FC 0 Club Leon 0 M04:00 | 06/11/21 | R 17 Puebla FC 1 Deportivo Toluca FC 0 M02:00 | 22/11/21 | R 1 Deportivo Toluca FC 1 Pumas Unam 2 |
| 7 | |  Puebla FC | 17 | 6 | 6 | 5 | 16 | 16 | 0 | 24 | M01:00 | 24/10/21 | R 15 Puebla FC 0 Club Leon 1 G05:00 | 30/10/21 | R 16 FC Juarez 0 Puebla FC 2 G04:00 | 06/11/21 | R 17 Puebla FC 1 Deportivo Toluca FC 0 G06:00 | 21/11/21 | R 1 Puebla FC (6) 2 Guadalajara Chivas (5) 2 G04:00 | 26/11/21 | R quarterfinal Puebla FC 2 Club Leon 1 M05:05 | 29/11/21 | R quarterfinal Club Leon 2 Puebla FC 0 |
| 8 | |  Cruz Azul | 17 | 5 | 8 | 4 | 21 | 17 | 4 | 23 | B05:05 | 20/10/21 | R 14 Atlas FC 0 Cruz Azul 0 B05:00 | 24/10/21 | R 15 Guadalajara Chivas 1 Cruz Azul 1 G02:05 | 01/11/21 | R 16 Cruz Azul 2 CF America 1 M06:00 | 04/11/21 | R 11 Cruz Azul 0 Club Leon 1 M02:00 | 08/11/21 | R 17 Pumas Unam 4 Cruz Azul 3 M04:15 | 22/11/21 | R 1 Cruz Azul 1 CF Monterrey 4 |
| 9 | |  CF Monterrey | 17 | 5 | 7 | 5 | 19 | 16 | 3 | 22 | M01:06 | 24/10/21 | R 15 CF Monterrey 0 Necaxa 1 B04:05 | 01/11/21 | R 16 Atletico San Luis 1 CF Monterrey 1 B04:00 | 07/11/21 | R 17 CF America 0 CF Monterrey 0 G04:15 | 22/11/21 | R 1 Cruz Azul 1 CF Monterrey 4 B06:05 | 25/11/21 | R quarterfinal CF Monterrey 0 Atlas FC 0 B06:05 | 28/11/21 | R quarterfinal Atlas FC 1 CF Monterrey 1 |
| 10 | |  Guadalajara Chivas | 17 | 5 | 7 | 5 | 13 | 13 | 0 | 22 | G01:00 | 18/10/21 | R 13 Guadalajara Chivas 2 Deportivo Toluca FC 0 B05:06 | 21/10/21 | R 14 Club Tijuana de Caliente 0 Guadalajara Chivas 0 B05:00 | 24/10/21 | R 15 Guadalajara Chivas 1 Cruz Azul 1 M05:10 | 31/10/21 | R 16 Tigres UANL 2 Guadalajara Chivas 1 G06:00 | 06/11/21 | R 17 Mazatlan FC 0 Guadalajara Chivas 1 M06:00 | 21/11/21 | R 1 Puebla FC (6) 2 Guadalajara Chivas (5) 2 |
| 11 | |  Pumas Unam | 17 | 5 | 6 | 6 | 17 | 23 | -6 | 21 | G02:00 | 08/11/21 | R 17 Pumas Unam 4 Cruz Azul 3 G02:00 | 22/11/21 | R 1 Deportivo Toluca FC 1 Pumas Unam 2 B04:00 | 25/11/21 | R quarterfinal Pumas Unam 0 CF America 0 G04:00 | 28/11/21 | R quarterfinal CF America 1 Pumas Unam 3 M06:00 | 03/12/21 | R semifinal Pumas Unam 0 Atlas FC 1 G04:00 | 06/12/21 | R semifinal Atlas FC 0 Pumas Unam 1 |
| 12 | |  Atletico San Luis | 17 | 4 | 8 | 5 | 19 | 23 | -4 | 20 | M03:00 | 17/10/21 | R 13 Atletico San Luis 0 CF America 1 M03:00 | 25/10/21 | R 15 Atletico San Luis 2 Atlas FC 6 B04:05 | 01/11/21 | R 16 Atletico San Luis 1 CF Monterrey 1 B04:00 | 04/11/21 | R 5 CF Pachucha 0 Atletico San Luis 0 B04:06 | 08/11/21 | R 17 Club Santos Laguna 0 Atletico San Luis 0 M04:00 | 21/11/21 | R 1 Club Santos Laguna 2 Atletico San Luis 0 |
| 13 | |  Mazatlan FC | 17 | 5 | 5 | 7 | 18 | 24 | -6 | 20 | M03:06 | 03/10/21 | R 12 Club Santos Laguna 1 Mazatlan FC 0 G05:00 | 16/10/21 | R 13 Mazatlan FC 1 Atlas FC 0 M03:00 | 20/10/21 | R 14 Puebla FC 2 Mazatlan FC 0 G05:00 | 23/10/21 | R 15 Mazatlan FC 2 Queretaro FC 1 M03:00 | 30/10/21 | R 16 Necaxa 2 Mazatlan FC 1 M06:00 | 06/11/21 | R 17 Mazatlan FC 0 Guadalajara Chivas 1 |
| 14 | |  Necaxa | 17 | 6 | 2 | 9 | 16 | 22 | -6 | 20 | B03:00 | 04/10/21 | R 12 Tigres UANL 0 Necaxa 0 M03:00 | 16/10/21 | R 13 Necaxa 0 Puebla FC 1 B03:00 | 21/10/21 | R 14 Deportivo Toluca FC 1 Necaxa 1 G01:06 | 24/10/21 | R 15 CF Monterrey 0 Necaxa 1 G03:00 | 30/10/21 | R 16 Necaxa 2 Mazatlan FC 1 M02:00 | 07/11/21 | R 17 Club Leon 3 Necaxa 0 |
| 15 | |  CF Pachucha | 17 | 4 | 6 | 7 | 19 | 21 | -2 | 18 | B03:00 | 17/10/21 | R 13 CF Pachucha 1 Club Santos Laguna 1 M05:00 | 21/10/21 | R 14 Tigres UANL 3 CF Pachucha 0 B05:00 | 25/10/21 | R 15 CF Pachucha 1 FC Juarez 1 B03:06 | 31/10/21 | R 16 CF Pachucha 1 Pumas Unam 1 B04:00 | 04/11/21 | R 5 CF Pachucha 0 Atletico San Luis 0 M06:06 | 07/11/21 | R 17 Club Tijuana de Caliente 3 CF Pachucha 2 |
| 16 | |  FC Juarez | 17 | 4 | 4 | 9 | 14 | 25 | -11 | 16 | G05:00 | 02/10/21 | R 12 FC Juarez 3 CF Monterrey 1 B03:00 | 09/10/21 | R 10 FC Juarez 0 Queretaro FC 0 M20:00 | 17/10/21 | R 13 Pumas Unam 1 FC Juarez 0 B05:00 | 25/10/21 | R 15 CF Pachucha 1 FC Juarez 1 M05:00 | 30/10/21 | R 16 FC Juarez 0 Puebla FC 2 M06:00 | 07/11/21 | R 17 Tigres UANL 3 FC Juarez 0 |
| 17 | |  Queretaro FC | 17 | 3 | 6 | 8 | 11 | 19 | -8 | 15 | B03:00 | 09/10/21 | R 10 FC Juarez 0 Queretaro FC 0 B04:00 | 15/10/21 | R 13 Queretaro FC 1 Club Tijuana de Caliente 1 G01:00 | 20/10/21 | R 14 Queretaro FC 1 CF Monterrey 0 M05:00 | 23/10/21 | R 15 Mazatlan FC 2 Queretaro FC 1 M01:00 | 31/10/21 | R 16 Queretaro FC 2 Club Santos Laguna 3 M06:00 | 05/11/21 | R 17 Atlas FC 2 Queretaro FC 0 |
| 18 | |  Club Tijuana de Caliente | 17 | 3 | 6 | 8 | 16 | 27 | -11 | 15 | M05:06 | 04/10/21 | R 12 Club Tijuana de Caliente 0 Cruz Azul 1 B04:00 | 15/10/21 | R 13 Queretaro FC 1 Club Tijuana de Caliente 1 B05:06 | 21/10/21 | R 14 Club Tijuana de Caliente 0 Guadalajara Chivas 0 M20:00 | 24/10/21 | R 15 Pumas Unam 3 Club Tijuana de Caliente 1 G03:00 | 29/10/21 | R 16 Atlas FC 0 Club Tijuana de Caliente 2 G06:06 | 07/11/21 | R 17 Club Tijuana de Caliente 3 CF Pachucha 2 |
