| 1 | |  FK Shkupi | 33 | 23 | 7 | 3 | 66 | 21 | 45 | 76 | G17:00 | 16/04/22 | R 28  Pelister Bitola 0 FK Shkupi 1 G17:00 | 23/04/22 | R 29 FK Shkupi 2 Renova Dzepciste 0 M18:00 | 30/04/22 | R 30 Bregalnica Stip 4 FK Shkupi 1 B18:00 | 04/05/22 | R 31 FK Shkupi 1 FK Makedonija Gjorge Petrov 1 B18:00 | 08/05/22 | R 32 FK Shkendija 0 FK Shkupi 0 G18:00 | 15/05/22 | R 33 FK Shkupi 3 FK Akademija Pandev Brera Strumica 0 |
| 2 | |  FK Akademija Pandev Brera Strumica | 33 | 19 | 7 | 7 | 55 | 32 | 23 | 64 | G17:00 | 17/04/22 | R 28 Renova Dzepciste 0 FK Akademija Pandev Brera Strumica 1 G17:00 | 22/04/22 | R 29 FK Akademija Pandev Brera Strumica 2 Bregalnica Stip 1 M18:00 | 01/05/22 | R 30 FK Makedonija Gjorge Petrov 1 FK Akademija Pandev Brera Strumica 0 G18:00 | 04/05/22 | R 31 FK Akademija Pandev Brera Strumica 4 FK Shkendija 2 G18:00 | 08/05/22 | R 32 FK Akademija Pandev Brera Strumica 2 Rabotnicki 1 M18:00 | 15/05/22 | R 33 FK Shkupi 3 FK Akademija Pandev Brera Strumica 0 |
| 3 | |  FK Shkendija | 33 | 16 | 13 | 4 | 49 | 25 | 24 | 61 | B17:00 | 17/04/22 | R 28 Bregalnica Stip 0 FK Shkendija 0 G17:00 | 23/04/22 | R 29 FK Shkendija 3 FK Makedonija Gjorge Petrov 1 G18:00 | 30/04/22 | R 30 FK Shkendija 1 Rabotnicki 0 M18:00 | 04/05/22 | R 31 FK Akademija Pandev Brera Strumica 4 FK Shkendija 2 B18:00 | 08/05/22 | R 32 FK Shkendija 0 FK Shkupi 0 B18:00 | 15/05/22 | R 33 FC Struga Trim Lum 1 FK Shkendija 1 |
| 4 | |  FK Makedonija Gjorge Petrov | 33 | 17 | 6 | 10 | 46 | 44 | 2 | 57 | G17:00 | 16/04/22 | R 28 FK Makedonija Gjorge Petrov 1 Rabotnicki 0 M17:00 | 23/04/22 | R 29 FK Shkendija 3 FK Makedonija Gjorge Petrov 1 G18:00 | 01/05/22 | R 30 FK Makedonija Gjorge Petrov 1 FK Akademija Pandev Brera Strumica 0 B18:00 | 04/05/22 | R 31 FK Shkupi 1 FK Makedonija Gjorge Petrov 1 M18:00 | 08/05/22 | R 32 FK Makedonija Gjorge Petrov 1 FC Struga Trim Lum 3 M18:00 | 15/05/22 | R 33 GFK Tikvesh 1930 2 FK Makedonija Gjorge Petrov 1 |
| 5 | |  Renova Dzepciste | 33 | 12 | 12 | 9 | 42 | 29 | 13 | 48 | M17:00 | 17/04/22 | R 28 Renova Dzepciste 0 FK Akademija Pandev Brera Strumica 1 M17:00 | 23/04/22 | R 29 FK Shkupi 2 Renova Dzepciste 0 B18:00 | 01/05/22 | R 30 Renova Dzepciste 1 FC Struga Trim Lum 1 G18:00 | 04/05/22 | R 31 GFK Tikvesh 1930 0 Renova Dzepciste 1 G18:00 | 08/05/22 | R 32 Renova Dzepciste 2 Skopje 0 G18:00 | 15/05/22 | R 33 FK Borec Veles 1 Renova Dzepciste 5 |
| 6 | |  FC Struga Trim Lum | 33 | 12 | 11 | 10 | 33 | 33 | 0 | 47 | M17:00 | 16/04/22 | R 28 FK Borec Veles 2 FC Struga Trim Lum 0 G17:00 | 23/04/22 | R 29 FC Struga Trim Lum 4 Pelister Bitola 0 B18:00 | 01/05/22 | R 30 Renova Dzepciste 1 FC Struga Trim Lum 1 G18:00 | 04/05/22 | R 31 FC Struga Trim Lum 1 Bregalnica Stip 0 G18:00 | 08/05/22 | R 32 FK Makedonija Gjorge Petrov 1 FC Struga Trim Lum 3 B18:00 | 15/05/22 | R 33 FC Struga Trim Lum 1 FK Shkendija 1 |
| 7 | |  Bregalnica Stip | 33 | 12 | 9 | 12 | 45 | 47 | -2 | 45 | B17:00 | 17/04/22 | R 28 Bregalnica Stip 0 FK Shkendija 0 M17:00 | 22/04/22 | R 29 FK Akademija Pandev Brera Strumica 2 Bregalnica Stip 1 G18:00 | 30/04/22 | R 30 Bregalnica Stip 4 FK Shkupi 1 M18:00 | 04/05/22 | R 31 FC Struga Trim Lum 1 Bregalnica Stip 0 G18:00 | 08/05/22 | R 32 Bregalnica Stip 1 GFK Tikvesh 1930 0 M18:00 | 15/05/22 | R 33 Skopje 4 Bregalnica Stip 1 |
| 8 | |  Rabotnicki | 33 | 13 | 4 | 16 | 29 | 35 | -6 | 43 | M17:00 | 16/04/22 | R 28 FK Makedonija Gjorge Petrov 1 Rabotnicki 0 M17:00 | 22/04/22 | R 29 Rabotnicki 0 Skopje 1 M18:00 | 30/04/22 | R 30 FK Shkendija 1 Rabotnicki 0 G18:00 | 04/05/22 | R 31 Rabotnicki 2 FK Borec Veles 1 M18:00 | 08/05/22 | R 32 FK Akademija Pandev Brera Strumica 2 Rabotnicki 1 G18:00 | 15/05/22 | R 33 Rabotnicki 2 Pelister Bitola 1 |
| 9 | |  Skopje | 33 | 9 | 8 | 16 | 27 | 45 | -18 | 35 | G17:00 | 22/04/22 | R 29 Rabotnicki 0 Skopje 1 M18:00 | 01/05/22 | R 30 FK Borec Veles 1 Skopje 0 G18:00 | 04/05/22 | R 31 Skopje 4 Pelister Bitola 2 M18:00 | 08/05/22 | R 32 Renova Dzepciste 2 Skopje 0 G18:00 | 15/05/22 | R 33 Skopje 4 Bregalnica Stip 1 G18:00 | 22/05/22 | R 1 Skopje 2 FK Belasica Strumica 1 |
| 10 | |  GFK Tikvesh 1930 | 33 | 9 | 7 | 17 | 36 | 38 | -2 | 34 | G17:00 | 23/04/22 | R 29 GFK Tikvesh 1930 5 FK Borec Veles 0 B18:00 | 01/05/22 | R 30 Pelister Bitola 1 GFK Tikvesh 1930 1 M18:00 | 04/05/22 | R 31 GFK Tikvesh 1930 0 Renova Dzepciste 1 M18:00 | 08/05/22 | R 32 Bregalnica Stip 1 GFK Tikvesh 1930 0 G18:00 | 15/05/22 | R 33 GFK Tikvesh 1930 2 FK Makedonija Gjorge Petrov 1 G18:00 | 22/05/22 | R 1 GFK Tikvesh 1930 4 Voska Sport 1 |
| 11 | |  FK Borec Veles | 33 | 5 | 6 | 22 | 25 | 66 | -41 | 21 | G17:00 | 16/04/22 | R 28 FK Borec Veles 2 FC Struga Trim Lum 0 M17:00 | 23/04/22 | R 29 GFK Tikvesh 1930 5 FK Borec Veles 0 G18:00 | 01/05/22 | R 30 FK Borec Veles 1 Skopje 0 M18:00 | 04/05/22 | R 31 Rabotnicki 2 FK Borec Veles 1 M18:00 | 08/05/22 | R 32 Pelister Bitola 2 FK Borec Veles 1 M18:00 | 15/05/22 | R 33 FK Borec Veles 1 Renova Dzepciste 5 |
| 12 | |  Pelister Bitola | 33 | 2 | 8 | 23 | 16 | 54 | -38 | 14 | M17:00 | 16/04/22 | R 28 Pelister Bitola 0 FK Shkupi 1 M17:00 | 23/04/22 | R 29 FC Struga Trim Lum 4 Pelister Bitola 0 B18:00 | 01/05/22 | R 30 Pelister Bitola 1 GFK Tikvesh 1930 1 M18:00 | 04/05/22 | R 31 Skopje 4 Pelister Bitola 2 G18:00 | 08/05/22 | R 32 Pelister Bitola 2 FK Borec Veles 1 M18:00 | 15/05/22 | R 33 Rabotnicki 2 Pelister Bitola 1 |
